Open AccessEffects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells
Author(s) -
Xiaojing Liu,
Li Yang,
Yong-Qiu Mao,
Qiong Wang,
Minghui Huang,
Yiping Wang,
Hongbin Wu
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i4.739
Subject(s) - genistein , hepatic stellate cell , microbiology and biotechnology , platelet derived growth factor receptor , flow cytometry , cell growth , biology , tyrosine kinase , cell cycle , cell , growth factor , endocrinology , signal transduction , biochemistry , receptor
Hepatic stellate cell (HSC) plays a pivotal role in liver fibrosis and is considered as the therapeutic target for the treatment of hepatic fibrosis. Tyrosine protein kinase plays an important role in the proliferation, activation of HSC. The purpose of the study is to investigate the effects of the tyrosine protein kinase inhibitor genistein on the proliferation and activation of cultured rat HSC.