Open AccessAnti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat
Author(s) -
Ai Hong Meng,
Yi Ling Ling,
Xiao Peng Zhang,
Jun Lan Zhang
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i4.712
Subject(s) - bronchoalveolar lavage , lipopolysaccharide , spleen , cholecystokinin , endocrinology , medicine , nitric oxide , phagocytosis , nitric oxide synthase , signal transduction , chemistry , immunology , lung , biochemistry , receptor
To study the anti-inflammatory effects of cholecystokinin-octapeptide (CCK-8) on lipopolysaccharide (LPS)-induced endotoxic shock (ES) and further investigate its signal transduction pathways involving p38 mitogen-activated protein kinase (MAPK) and IkappaB-alpha.