Open AccessStimulation of p38 MAPK by hormal preconditioning with atrial natriuretic peptide
Author(s) -
Alexandra K. Kiemer,
Stefanie Kulhanek-Heinze,
Tobias Gerwig,
Alexander L. Gerbes,
Angelika M. Vollmar
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i4.707
Subject(s) - atrial natriuretic peptide , p38 mitogen activated protein kinases , mapk/erk pathway , ischemia , reperfusion injury , medicine , ischemic preconditioning , stimulation , endocrinology , signal transduction , phosphorylation , pharmacology , chemistry , biochemistry
Stress-activated signaling pathways responsible for hepatic ischemia reperfusion injury and their modulation by protective interventions are widely unknown. Preconditioning of rat livers with Atrial Natriuretic Peptide (ANP) attenuates ischemia reperfusion injury (Gerbes et al. Hepatology 1998, 28:1309-1317). Since ANP has recently been shown to be a regulator of the p38 MAPK pathway in endothelial cells (Kiemer et al. Circ Res 2002, 90:874-881), aim of this study was to investigate activities of MAPK during ischemia and reperfusion and effects of ANP on MAPK.