The role of endotoxin, TNF-α, and IL-6 in inducing the state of growth hormone insensitivity | Zendy

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The role of endotoxin, TNF-α, and IL-6 in inducing the state of growth hormone insensitivity

Author(s) -

Ping Wang

Publication year - 2002

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v8.i3.531

Subject(s) - growth hormone receptor , endocrinology , medicine , proinflammatory cytokine , radioimmunoassay , receptor , hormone , messenger rna , sepsis , tumor necrosis factor alpha , cytokine , biology , growth hormone , inflammation , gene , biochemistry

Critical illnesses such as sepsis, trauma, and burns cause a growth hormone insensitivity, which leads to an increased negative nitrogen balance. Endotoxin is generously released into blood under these conditions and stimulates the production of proinflammatory cytokines such as TNF-alpha, IL-6, and IL-1, which may play a very important role in inducing the growth hormone insensitivity. The objective of this current study was to investigate the role of endotoxin, TNF-alpha and IL-6 in inducing the growth hormone insensitivity at the receptor and post-receptor levels.

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