Open AccessThe role of endotoxin, TNF-α, and IL-6 in inducing the state of growth hormone insensitivity
Author(s) -
Ping Wang,
Ning Li,
Jieshou Li,
Weiqin Li
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i3.531
Subject(s) - growth hormone receptor , endocrinology , medicine , proinflammatory cytokine , radioimmunoassay , receptor , hormone , messenger rna , sepsis , tumor necrosis factor alpha , cytokine , biology , growth hormone , inflammation , gene , biochemistry
Critical illnesses such as sepsis, trauma, and burns cause a growth hormone insensitivity, which leads to an increased negative nitrogen balance. Endotoxin is generously released into blood under these conditions and stimulates the production of proinflammatory cytokines such as TNF-alpha, IL-6, and IL-1, which may play a very important role in inducing the growth hormone insensitivity. The objective of this current study was to investigate the role of endotoxin, TNF-alpha and IL-6 in inducing the growth hormone insensitivity at the receptor and post-receptor levels.