Open AccessTGF-β1expression and angiogenesis in colorectal cancer tissue
Author(s) -
Bin Xiong,
Ling Gong,
Feng Zhang,
Ming-Bo Hu,
Huipin Yuan
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i3.496
Subject(s) - angiogenesis , colorectal cancer , transforming growth factor , cancer research , vascular endothelial growth factor , extracellular matrix , mouse model of colorectal and intestinal cancer , growth factor , transforming growth factor beta , cancer , medicine , biology , oncology , vegf receptors , microbiology and biotechnology , receptor
Transforming growth factor TGF beta1 is involved in a variety of important cellular functions,including cell growth and differentiation, angiogenesis, immune function and extracellular matrix formation. However, the role of TGF beta(1) as an angiogenic factor in colorectal cancer is still unclear. We investigate the relationship between transforming growth factor beta(1) and angiogenesis by analyzing the expression of transforming growth factor TGF beta(1) in colorectal cancer, as well as its association with VEGF and MVD.