Open AccessAntitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cellsin vitroandin vivo
Author(s) -
Fusheng Wang,
Mingxu Liu,
Bing Zhang,
Ming Shi,
Zhou-yun Lei,
WenHua Sun,
Qingyou Du,
Jumei Chen
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i3.464
Subject(s) - cytokine induced killer cell , peripheral blood mononuclear cell , cytotoxic t cell , lymphokine activated killer cell , immunotherapy , cytokine , immunology , monoclonal antibody , cd3 , interleukin 2 , biology , cancer research , in vitro , t cell , medicine , antibody , interleukin 21 , cd8 , immune system , biochemistry
To characterize the anticancer function of cytokine-induced killer cells (CIK) and develop an adoptive immunotherapy for the patients with primary hepatocellular carcinoma (HCC), we evaluated the proliferation rate, phenotype and the antitumor activity of human CIK cells from healthy donors and HCC patients in vitro and in vivo.