Open AccessInhibition of human telomerase in MKN-45 cell line by antisense hTR expression vector induces cell apoptosis and growth arrest
Author(s) -
Runhua Feng,
Zhenggang Zhu,
Jianfang Li,
Binya Liu,
Min Yan,
Hao Yin,
Yuxin Lin
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i3.436
Subject(s) - transfection , microbiology and biotechnology , telomerase , biology , sense (electronics) , telomerase reverse transcriptase , complementary dna , cell cycle , expression vector , cell culture , antisense rna , flow cytometry , gene expression , apoptosis , gene , recombinant dna , chemistry , genetics
To investigate the effects of antisense human telomerase RNA (hTR)on the biologic behavior of human gastric cancer cell line: MKN-45 by gene transfection and its potential role in the gene therapy of gastric cancer.