Open AccessInfluencing factors of pancreatic microcirculatory impairment in acute panceatitis
Author(s) -
Zong-Guang Zhou
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i3.406
Subject(s) - medicine , microcirculation , acute pancreatitis , pathogenesis , ischemia , pancreatitis , vasoconstriction , bradykinin , nitric oxide , vascular permeability , vasospasm , perfusion , cardiology , pathology , subarachnoid hemorrhage , receptor
Pancreatic microcirculatory disturbance plays an important role in th e pathogenesis of acute pancreatitis, and it involves a series of changes including vasoconstriction, ischaemia, increased vascular permeability, impairment of nutritive tissue perfusion, ischaemia/reperfusion, leukocyte adherence, hemorrheological changes and impaired lymphatic drainage. Ischaemia possibly acts as an initiating factor of pancreatic microcirculatory injury in acute pancreatitis, or as an aggravating/continuing mechanism. The end-artery feature of the intralobular arterioles suggests that the pancreatic microcirculation is highly susceptible to ischaemia. Various vasoactive mediators, as bradykinin, platelet activating factor, endothelin and nitric oxide participate in the development of microcirculatory failure.