Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene | Zendy

Lizong Shen | Zendy; WU Wen-xi | Zendy; Dehua Xu | Zendy; Zhongcheng Zheng | Zendy; Xinyuan Liu | Zendy; Qiang Ding | Zendy; Yibing Hua | Zendy; Kun Yao | Zendy

Open Access

Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene

Author(s) -

Lizong Shen,

WU Wen-xi,

Dehua Xu,

Zhongcheng Zheng,

Xinyuan Liu,

Qiang Ding,

Yibing Hua,

Kun Yao

Publication year - 2002

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v8.i2.270

Subject(s) - microbiology and biotechnology , cytosine deaminase , recombinant dna , cytotoxic t cell , viral vector , biology , virology , suicide gene , genetic enhancement , cell culture , hela , chemistry , gene , in vitro , biochemistry , genetics

To kill CEA positive colorectal carcinoma cells specifically using the E coli cytosine deaminase (CD) suicide gene, a new replication-deficient recombinant adenoviral vector was constructed in which CD gene was controlled under CEA promoter and its in vitro cytotoxic effects were evaluated.

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