Open AccessTranscription factor EGR-1 inhibits growth of hepatocellular carcinoma and esophageal carcinoma cell lines
Author(s) -
Ming Hao,
Ying-Rui Liang,
Yanfang Liu,
Li Liu,
Mingyao Wu,
Huan-Xing Yang
Publication year - 2002
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v8.i2.203
Subject(s) - transfection , cell growth , cell culture , cancer research , biology , transcription factor , cell , hepatocellular carcinoma , microbiology and biotechnology , gene , genetics , biochemistry
The transcription factor EGR-1 (early growth response gene-1) plays an important role in cell growth, differentiation and development. It has identified that EGR-1 has significant transformation suppression activity in some neoplasms, such as fibrosarcoma, breast carcinoma. This experiment was designed to investigate the role of egr-1 in the cancerous process of hepatocellular carcinoma (HCC) and esophageal carcinoma (EC), and then to appraise the effects of EGR-1 on the growth of these tumor cells.