Open AccessCytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle, Fujian Province
Author(s) -
Liangchun Cai,
ShunZhang Yu,
Zhenyu Zhan
Publication year - 2001
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v7.i6.792
Subject(s) - genotype , cyp2e1 , odds ratio , medicine , gastroenterology , cancer , case control study , carcinogen , population , liver cancer , genetics , biology , cytochrome p450 , gene , environmental health , metabolism
Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 (CYP2E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitrosoamines and low molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2E1 polymorphisms are associated with risks of gastric cancer.