Open AccessInhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis
Author(s) -
Qing He Nie,
Yong Cheng,
Yu Mei Xie,
Yong Zhou,
Yi Cao
Publication year - 2001
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v7.i3.363
Subject(s) - hepatic fibrosis , immunohistochemistry , fibrosis , microbiology and biotechnology , in situ hybridization , hepatic stellate cell , in vivo , gene expression , chemistry , pathology , biology , gene , medicine , biochemistry
To observe the inhibition of antisense oligonucleotides (asON) phosphorthioate to the tissue inhibitors metalloproteinase-1 (TIMP-1) gene and protein expression in the liver tissue of immunologically induced hepatic fibrosis rats. The possibility of reversing hepatic fibrosis through gene therapy was observed.