Open AccessEffects of aminoguanidine on nitric oxide production induced by inflammatory cytokines and endotoxin in cultured rat hepatocytes
Author(s) -
Guo Liang Zhang
Publication year - 2001
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v7.i3.331
Subject(s) - nitric oxide , lipopolysaccharide , in vitro , dexamethasone , intracellular , nitric oxide synthase , nitroarginine , microbiology and biotechnology , arginine , chemistry , tumor necrosis factor alpha , ic50 , pharmacology , medicine , endocrinology , biochemistry , biology , amino acid
To study the effects of aminoguanidine (AG) and two L-arginine analogues N(omega)-nitro-L-arginine methyl ester (L-NAME) and N(omega)-nitro-L-arginine (L-NNA) on nitric oxide (NO) production induced by cytokines (TNF-alpha, IL-1 beta, and IFN-gamma) and bacterial lipopolysaccharide (LPS) mixture (CM) in the cultured rat hepatocytes, and examine their mechanisms action.