Open AccessExperimental research on phospholipids variation of halothane on liver mitochondria
Author(s) -
Simona Bo,
Guangming Zhang,
Weifeng Yu,
Xuemin Wang,
Yong-De Ma,
Shu-Xiao Liu
Publication year - 1999
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v5.i1.28
Subject(s) - halothane , mitochondrion , pathogenesis , high performance liquid chromatography , chemistry , inner mitochondrial membrane , sevoflurane , membrane , biochemistry , chromatography , pharmacology , medicine , pathology , organic chemistry
AIM:To study the pathogenesis of hepatotoxicity of halothane.METHODS:The effect of different concentration of halothane and sevoflurane on mitochondrial membrane phospholipids composition of rat liver were analyzed using high performance liquid chromatography (HPLC) technology.RESULTS:Halothane at low concentration could degrade mitochondrial membrane major phospholipids and increase lysophosph-atidylcholine.CONCLUSION:The pathogenesis of halothane hepatotoxicity was the phospholipids variation on liver mitochondria.