Open AccessInteraction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721)
Author(s) -
Weixue Tang
Publication year - 1998
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v4.i5.418
Subject(s) - cisplatin , drug , fluorouracil , pharmacology , vincristine , medicine , cell culture , drug interaction , chemotherapy , chemistry , biology , genetics , cyclophosphamide
AIM:To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721).METHODS:The median-effect principle was used.RESULTS:Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI > 1), and synergism was achiened when CI < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration.CONCLUSION:The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.