Interaction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721) | Zendy

Weixue Tang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Interaction between cisplatin, 5-fluorouracil and vincristine on human hepatoma cell line (7721)

Author(s) -

Weixue Tang

Publication year - 1998

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v4.i5.418

Subject(s) - cisplatin , drug , fluorouracil , pharmacology , vincristine , medicine , cell culture , drug interaction , chemotherapy , chemistry , biology , genetics , cyclophosphamide

AIM:To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721).METHODS:The median-effect principle was used.RESULTS:Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI > 1), and synergism was achiened when CI < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration.CONCLUSION:The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research