Open AccessTelomeric associations of chromosomes in patients with esophageal squamous cell carcinomas
Author(s) -
Lin Xiao
Publication year - 1998
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v4.i3.231
Subject(s) - chromosome instability , chromosome , esophageal squamous cell carcinoma , telomere , biology , esophageal cancer , cell , peripheral blood , pathology , cancer , cancer research , medicine , genetics , oncology , dna , gene , immunology
AIM:To investigate the role of telomeric association in the development of esophageal cancer.METHODS:Using chromosome R banding technique,telomeric association of chromosome in peripheral blood lymphocytes from 16 untreated patients with esophageal squamous cell carcinoma were observed and 16 healthy adults served as controls.RESULTS:The teloemeric association frequencies of cell and chromosomes were significantly higher than those of controls(X(2) = 9.56,P <0.01), but its distribution on the chromosome showed no significant difference (X(2) =1.01, P >0.05) between the two groups.CONCLUSION:Chromosomal instability can be initiated by telomeric associations, and sequential chromosome analysis can aid the understanding of the tumor occurrence and progression.