Open AccessExpression of bcl-2 protein in gastric carcinoma and its significance
Author(s) -
Haifeng Liu
Publication year - 1998
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v4.i3.228
Subject(s) - immunohistochemistry , carcinogenesis , pathology , staining , tumor progression , gastric carcinoma , biology , carcinoma , lymph node , cancer research , cancer , medicine
AIM:To further study the role of bcl-2 protein expression in gastric carcinogenesis and tumor progression.METHODS:Using immunohistochemical staining, the bcl-2 protein expression in 50 cases of gastric carcinoma and its relation to clinical status and pathomorphological parameters were observed.RESULTS:Forty-one (82%) cases were positive for bcl-2 protein staining which was located in the cytoplasm and nuclear membrane of tumor cells. The rate of bcl-2 protein expression was not correlated with the patient, sex, tumor size, lymph node status or clinical stages (P > 0.05). It was strongly associated with intestinal-type tumors and poorly differentiated tumors (P < 0.05 andP <0.01).CONCLUSION:Aberrant bcl-2 protein expression appears to be specifically associated with development of intestinal-type gastric carcinoma, bcl-2 protein expression might play an important role in the early development/promotion and phenotypic differentiation of gastric carcinomas, but not in tumor progression.