Open AccessEffects of endotoxin on expression of ras, p53 and bcl-2 oncoprotein in hepatocarcinogenesis induced by thioacetamide in rats
Author(s) -
JinMing Yang,
DeWu Han,
Quan-Chen Liang,
Jiali Zhao,
Su-Yuan Hao,
Xuehui Ma,
Yuanchang Zhao
Publication year - 1997
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v3.i4.213
Subject(s) - thioacetamide , oncogene , cancer research , carcinogenesis , biology , cell cycle , flow cytometry , hepatocyte , malignant transformation , gene expression , gene knockdown , cell , cancer , gene , microbiology and biotechnology , endocrinology , in vitro , biochemistry , genetics
To evaluate the relationship between expression of ras, p53 and bcl-2 gene products and hepatocarcinogenesis since the endotoxemia produced from lipopolysaccharide administration and/or the hypophagocytic state of splenectomy significantly accelerated hepatocarcinogenesis induced by thioacetamide.