Open AccessMucosal bacterial dysbiosis in patients with nodular lymphoid hyperplasia in the terminal ileum
Author(s) -
Qiaoli Jiang,
You Lü,
Mengjie Zhang,
Zhenyu Cui,
Zhong-Mei Pei,
Wenhua Li,
Lungen Lu,
Jingjing Wang,
Yingying Lü
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i8.811
Subject(s) - dysbiosis , microbiome , gastroenterology , immune system , gut flora , biology , medicine , immunology , bioinformatics
Nodular lymphoid hyperplasia (NLH) in the small intestine is a rare benign lesion characterized by multiple small nodules on the intestinal surface. Patients with terminal ileal NLH may experience long-term abdominal pain, diarrhea, and abdominal distension, among other symptoms. Supplementation with probiotics could mitigate these symptoms. NLH is linked to the immune system, and it may result from accumulation of plasma-cell precursors due to a maturational defect during the development of B lymphocytes. The intestinal microbiome plays an essential role in the immune system. Thus, we speculate that the gut flora plays a key role in terminal ileal NLH.