Open AccessGastrointestinal tumors in transplantation: Two case reports and review of literature
Author(s) -
Romain Stammler,
Dany Anglicheau,
Bruno Landi,
Tchao Méatchi,
Emilia Ragot,
Éric Thervet,
Hélène Lazareth
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i34.5076
Subject(s) - gist , medicine , gastrointestinal tract , transplantation , stromal tumor , complication , gastroenterology , surgery , stromal cell , oncology
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. As most of them harbor a KIT mutation (75%), selective kinase inhibitors are the therapeutic option and show a sustained objective response among patients with metastatic or unresectable GISTs. A well-known higher risk of neoplasm has been described among renal transplant recipients (RTRs). Nevertheless, only few cases of GIST onset among transplant patients have been reported in the literature.