Open AccessNovel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models
Author(s) -
Alissar Monzer,
Kevork Wakimian,
Farah Ballout,
Samar Al Bitar,
Amani Yehya,
Mariam Kanso,
Nour Saheb,
Ayman Tawil,
Samer Doughan,
Maher Hussein,
Deborah Mukherji,
Walid Faraj,
Hala GaliMuhtasib,
Wassim AbouKheir
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i33.4787
Subject(s) - colorectal cancer , cancer research , cancer , cancer stem cell , cell growth , pi3k/akt/mtor pathway , viability assay , cell culture , cancer cell , protein kinase b , apoptosis , biology , medicine , biochemistry , genetics
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality. Cancer stem cells (CSCs) in CRC, which are spared by many chemotherapeutics, have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone (DIQ) has shown promising effects on targeting colon cancer. However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.