Open AccessAnoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer
Author(s) -
Tomoyuki Fukami,
Atsushi Shiozaki,
Toshiyuki Kosuga,
Michihiro Kudou,
Hiroki Shimizu,
Takuma Ohashi,
Tomohiro Arita,
Hirotaka Konishi,
Shuhei Komatsu,
Takeshi Kubota,
Hitoshi Fujiwara,
Kazuma Okamoto,
Mitsuo Kishimoto,
Yukiko Morinaga,
Eiichi Konishi,
Eigo Otsuji
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i32.4649
Subject(s) - gene knockdown , cell cycle , cell growth , biology , gene silencing , cancer research , cell , microbiology and biotechnology , apoptosis , chemistry , biochemistry , gene
Anoctamin 5 (ANO5)/transmembrane protein 16E belongs to the ANO/ transmembrane protein 16 anion channel family. ANOs comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell types. Previous studies have elucidated the roles and mechanisms of ANO5 activation in various cancer types. However, it remains unclear whether ANO5 acts as a plasma membrane chloride channel, and its expression and functions in gastric cancer (GC) have not been investigated.