Open AccessAlcohol-related diseases and liver metastasis: Role of cell-free network communication
Author(s) -
Manuel Muro,
Aurelia Collados-Ros,
Isabel Legáz
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i30.4231
Subject(s) - microvesicles , metastasis , disease , alcohol consumption , cancer , liver cancer , cell signaling , medicine , bioinformatics , signal transduction , cancer research , immunology , biology , alcohol , microrna , gene , genetics , biochemistry
Alcohol intake is a risk factor for cancer development and metastatic disease progression. Extracellular vesicle (EV)-mediated interorgan communication is assumed to be significant in boosting tumorigenic pathways and disease progression. Recent research indicates that exosomes have a variety of roles in the development of cancer during pathophysiological conditions. The involvement of EV signaling during cancer progression in the alcohol environment is unknown. Therefore, understanding communication networks and the role of EVs as biomarkers can contribute significantly to developing strategies to address the serious public health problems associated with alcohol consumption and cancer.