Open AccessHP0953 hypothetical protein overexpresses and localization as virulence factor from Helicobacter pylori during infection to gastric epithelium cells
Author(s) -
Nancy K Arteaga-Resendiz,
Gerardo E Rodea,
Rosa María RibasAparicio,
Alma L Olivares-Cervantes,
Juan Arturo Castelán-Vega,
José de Jesús Olivares-Trejo,
Sandra Mendoza-Elizalde,
Edgar Óliver López-Villegas,
Christian Colín,
Pamela Aguilar-Rodea,
Alfonso ReyesLópez,
Martínez García,
Norma Velázquez-Guadarrama
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i29.3886
Subject(s) - virulence , biology , helicobacter pylori , virulence factor , immunogold labelling , microbiology and biotechnology , signal peptide , recombinant dna , antibody , immunology , gene , genetics
The high prevalence and persistence of Helicobacter pylori ( H. pylori ) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340 hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.