Open AccessApplication of intravoxel incoherent motion diffusion-weighted imaging in hepatocellular carcinoma
Author(s) -
Yi Zhou,
Jing Zheng,
Cui Yang,
Juan Peng,
Ning Liu,
Lin Yang,
Xiaoming Zhang
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i27.3334
Subject(s) - intravoxel incoherent motion , grading (engineering) , medicine , hepatocellular carcinoma , pathological , diffusion mri , effective diffusion coefficient , microcirculation , perfusion , radiology , nuclear medicine , pathology , magnetic resonance imaging , civil engineering , engineering
The morbidity and mortality of hepatocellular carcinoma (HCC) rank 6 th and 4 th , respectively, among malignant tumors worldwide. Traditional diffusion-weighted imaging (DWI) uses the apparent diffusion coefficient (ADC) obtained by applying the monoexponential model to reflect water molecule diffusion in active tissue; however, the value of ADC is affected by microcirculation perfusion. Using a biexponential model, intravoxel incoherent motion (IVIM)-DWI quantitatively measures information related to pure water molecule diffusion and microcirculation perfusion, thus compensating for the shortcomings of DWI. The number of studies examining the application of IVIM-DWI in patients with HCC has gradually increased over the last few years, and many results show that IVIM-DWI has vital value for HCC differentiation, pathological grading, and predicting and evaluating the treatment response. The present study principally reviews the principle of IVIM-DWI and its research progress in HCC differentiation, pathological grading, predicting and evaluating the treatment response, predicting postoperative recurrence and predicting gene expression prediction.