Open AccessIntermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome
Author(s) -
Shu Tang,
Cheng-Hong Liang,
Yalei Liu,
Wei Wei,
Xinru Deng,
Xiasheng Shi,
Limin Wang,
Lijun Zhang,
Huijuan Yuan
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i21.2320
Subject(s) - obstructive sleep apnea , medicine , hypopnea , gastroenterology , insulin resistance , diabetes mellitus , intermittent hypoxia , type 2 diabetes mellitus , type 2 diabetes , metabolic syndrome , sleep apnea , gut flora , hypoxia (environmental) , endocrinology , obesity , apnea , polysomnography , immunology , chemistry , oxygen , organic chemistry
Obstructive sleep apnea (OSA)-hypopnea syndrome (OSAHS) has been recognized as a comorbidity of type 2 diabetes mellitus (T2DM); more than half of T2DM patients suffer from OSAHS. Intermittent hypoxia (IH) plays an important role in metabolic diseases, such as obesity and OSAHS, through various mechanisms, including altering the gut microecological composition and function. Therefore, it is important to study the role of gut microbiota in T2DM patients with OSAHS, which has a high incidence and is prone to several complications.