Open AccessFusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model
Author(s) -
Na Wu,
Yuqing Feng,
Na Lyu,
Di Wang,
Weidong Yu,
Yongfei Hu
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i18.1981
Subject(s) - fusobacterium nucleatum , azoxymethane , transcriptome , colorectal cancer , gut flora , dysbiosis , biology , microbiome , cancer research , microbiology and biotechnology , immunology , medicine , cancer , gene expression , bioinformatics , bacteria , gene , genetics , porphyromonas gingivalis
Fusobacterium nucleatum ( F. nucleatum ) has long been known to cause opportunistic infections and has recently been implicated in colorectal cancer (CRC), which has attracted broad attention. However, the mechanism by which it is involved in CRC development is not fully understood.