Open AccessEffect of ancient Khorasan wheat on gut microbiota, inflammation, and short-chain fatty acid production in patients with fibromyalgia
Author(s) -
Simone Baldi,
Giuditta Pagliai,
Monica Dinu,
Leandro Di Gloria,
Giulia Nannini,
Lavinia Curini,
Marco Pallecchi,
Edda Russo,
Eleiccolai,
Giovanna Danza,
Stefano Benedettelli,
Giovanna Ballerini,
Barbara Colombini,
Gianluca Bartolucci,
Matteo Ramazzotti,
Francesco Sofi,
Amedeo Amedei
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i18.1965
Subject(s) - irritable bowel syndrome , crossover study , feces , gut flora , fibromyalgia , fatty acid , medicine , food science , short chain fatty acid , gastroenterology , biology , physiology , zoology , immunology , biochemistry , placebo , microbiology and biotechnology , alternative medicine , pathology , fermentation , butyrate
Fibromyalgia (FM) syndrome is mainly characterized by widespread pain, sleeping disorders, fatigue, and cognitive dysfunction. In many cases, gastrointestinal distress is also reported, suggesting the potential pathogenic role of the gut microbiota (GM). The GM is deeply influenced by several environmental factors, especially the diet, and recent findings highlighted significant symptom improvement in FM patients following various nutritional interventions such as vegetarian diet, low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols based diets, gluten-free diet, and especially an ancient grain supplementation. In particular, a recent study reported that a replacement diet with ancient Khorasan wheat led to an overall improvement in symptom severity of FM patients.