Open AccessQuercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells
Author(s) -
HsiLung Hsieh,
MingChin Yu,
LiChing Cheng,
Mei-Yi Chu,
Tzu-Hao Huang,
TaSen Yeh,
Ming-Ming Tsai
Publication year - 2022
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v28.i11.1139
Subject(s) - tumor necrosis factor alpha , viability assay , inflammation , quercetin , cancer research , microbiology and biotechnology , biology , cell , chemistry , immunology , biochemistry , antioxidant
Gastric injury is the most common digestive system disease worldwide and involves inflammation, which can lead to gastric ulcer or gastric cancer (GC). Matrix metallopeptidase-9 [MMP-9 (gelatinase-B)] plays an important role in inflammation and GC progression. Quercetin and quercetin-rich diets represent potential food supplements and a source of medications for treating gastric injury given their anti-inflammatory activities. However, the effects and mechanisms of action of quercetin on human chronic gastritis and whether quercetin can relieve symptoms remain unclear.