Open AccessAbdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway
Author(s) -
Sung-Wei Huang,
Yi Wen,
Haiyan Sun,
Jie Deng,
Yaolei Zhang,
Qilin Huang,
Bing Wang,
Zhigang Luo,
Lijun Tang
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i9.815
Subject(s) - hmgb1 , acute pancreatitis , medicine , inflammation , pancreatitis , tlr4 , gastroenterology , paracentesis , ascites
Our previous studies confirmed that abdominal paracentesis drainage (APD) attenuates intestinal mucosal injury in rats with severe acute pancreatitis (SAP), and improves administration of enteral nutrition in patients with acute pancreatitis (AP). However, the underlying mechanisms of the beneficial effects of APD remain poorly understood.