Open AccessEffect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats
Author(s) -
Jindong Zhao,
Yan Li,
Min Sun,
Chanjuan Yu,
Jiayun Li,
Si-Hai Wang,
Daizhi Yang,
Chenglin Guo,
Xue Du,
Wenjin Zhang,
Ruo-Dong Cheng,
Xiao-Chuan Diao,
Zhaohui Fang
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i8.708
Subject(s) - berberine , type 2 diabetes , gut flora , composition (language) , medicine , diabetes mellitus , biology , endocrinology , chemistry , food science , pharmacology , immunology , linguistics , philosophy
A recent investigation showed that the prevalence of type 2 diabetes mellitus (T2DM) is 12.8% among individuals of Han ethnicity. Gut microbiota has been reported to play a central role in T2DM. Goto-Kakizaki (GK) rats show differences in gut microbiota compared to non-diabetic rats. Previous studies have indicated that berberine could be successfully used to manage T2DM. We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.