Open AccessDetailing the ultrastructure’s increase of prion protein in pancreatic adenocarcinoma
Author(s) -
Matteo Bianchini,
Maria Giambelluca,
Maria Concetta Scavuzzo,
Gregorio Di Franco,
Simone Guadagni,
Matteo Palmeri,
Niccolò Furbetta,
Desirée Gianardi,
Niccola Funel,
Claudio Ricci,
Raffaele Gaeta,
Luca Emanuele Pollina,
Alfredo Falcone,
Caterina Vivaldi,
Giulio Di Candio,
Francesca Biagioni,
Carla Letizia Busceti,
Luca Morelli,
Francesco Fornai
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i42.7324
Subject(s) - compartmentalization (fire protection) , pancreatic cancer , adenocarcinoma , pathology , biology , ultrastructure , blot , protein expression , immunohistochemistry , cancer research , cancer , medicine , gene , enzyme , biochemistry
Recent evidences have shown a relationship between prion protein (PrPc) expression and pancreatic ductal adenocarcinoma (PDAC). Indeed, PrPc could be one of the markers explaining the aggressiveness of this tumor. However, studies investigating the specific compartmentalization of increased PrPc expression within PDAC cells are lacking, as well as a correlation between ultrastructural evidence, ultrastructural morphometry of PrPc protein and clinical data. These data, as well as the quantitative stoichiometry of this protein detected by immuno-gold, provide a significant advancement in understanding the biology of disease and the outcome of surgical resection.