Open AccessImpact of Helicobacter pylori infection on gut microbiota
Author(s) -
Chikara Iino,
Tadashi Shimoyama
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i37.6224
Subject(s) - gut flora , helicobacter pylori , biology , antibiotics , stomach , feces , population , microbiology and biotechnology , immunology , medicine , biochemistry , genetics , environmental health
A number of studies have revealed the association between Helicobacter pylori ( H. pylori ) infection and the gut microbiota. More than half of the investigations on the impact of H. pylori on the gut microbiota have been the sub-analyses of the influence of eradication therapy. It was observed that H. pylori eradication altered gut microbiota within a short period after eradication, and majority of the alterations took a long period of time to reverse back to the original. Changes in the gut microbiota within a short period after eradication may be attributed to antibiotics and proton pump inhibitors. Modification of gastric acidity in the stomach caused by a long-term H. pylori infection alters the gut microbiota. Analysis of the gut microbiota should be conducted in a large population, adjusting for considerable biases associated with the composition of the gut microbiota, such as age, sex, body mass index, diet and the virulence of H. pylori .