Open AccessSignificance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases
Author(s) -
Satya Priya Sharma,
Ki Tae Suk,
Dong Joon Kim
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i37.6161
Subject(s) - fatty liver , gut flora , dysbiosis , alcoholic liver disease , nonalcoholic fatty liver disease , overnutrition , biology , alcoholic fatty liver , alcoholic hepatitis , liver disease , liver injury , disease , medicine , physiology , immunology , endocrinology , obesity , cirrhosis
Liver-gut communication is vital in fatty liver diseases, and gut microbes are the key regulators in maintaining liver homeostasis. Chronic alcohol abuse and persistent overnutrition create dysbiosis in gut ecology, which can contribute to fatty liver disease. In this review, we discuss the gut microbial compositional changes that occur in alcoholic and nonalcoholic fatty liver diseases and how this gut microbial dysbiosis and its metabolic products are involved in fatty liver disease pathophysiology. We also summarize the new approaches related to gut microbes that might help in the diagnosis and treatment of fatty liver disease.