Open AccessImpact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study
Author(s) -
Valentina Brancato,
Nunzia Garbino,
Lorenzo Mannelli,
Marco Aiello,
Marco Salvatore,
Monica Franzese,
Carlo Cavaliere
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i36.6110
Subject(s) - radiogenomics , medicine , esophageal cancer , oncology , cancer , radiology , radiomics
Esophageal cancer (ESCA) is the sixth most common malignancy in the world, and its incidence is rapidly increasing. Recently, several microRNAs (miRNAs) and messenger RNA (mRNA) targets were evaluated as potential biomarkers and regulators of epigenetic mechanisms involved in early diagnosis. In addition, computed tomography (CT) radiomic studies on ESCA improved the early stage identification and the prediction of response to treatment. Radiogenomics provides clinically useful prognostic predictions by linking molecular characteristics such as gene mutations and gene expression patterns of malignant tumors with medical images and could provide more opportunities in the management of patients with ESCA.