Open AccessAssociation of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer
Author(s) -
Levar Shamoun,
Kalle Landerholm,
Amanda Balboa Ramilo,
Roland Andersson,
Jan Dimberg,
Dick Wågsäter
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i30.5076
Subject(s) - colorectal cancer , ccl4 , chemokine , carcinogenesis , single nucleotide polymorphism , taqman , biology , cancer research , pathology , medicine , cancer , immunology , gene , real time polymerase chain reaction , genotype , inflammation , chemistry , genetics , carbon tetrachloride , organic chemistry
Leukocytes, such as T cells and macrophages, play an important role in tumorigenesis. CC chemokine ligand (CCL) 4, which is produced by lymphocytes and macrophages, has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.