Open AccessSerum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B
Author(s) -
Caizhi Huang,
Jie Zhang,
Lin Zhong,
Cui-Hua Yu,
Ming Yi,
Liya Mo
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i3.255
Subject(s) - hbsag , hbeag , vitamin d and neurology , vitamin d binding protein , hepatitis b virus , medicine , hepatitis b , vitamin , liver function , gastroenterology , immunology , virus
Vitamin D is an essential fat-soluble secosteroid hydroxylated by the liver to form the intermediate metabolite calcidiol {25-hydroxy vitamin D [25(OH)D]}, which is a reliable indicator to investigate individual vitamin D status. Vitamin-D-binding protein (VDBP) is a multifunctional glycoprotein mainly synthesized in the liver and the major transport protein for vitamin D and its metabolites. Serum vitamin D and VDBP are both associated with hepatitis B. However, few studies have reported the relationship and clinical significance of vitamin D and VDBP with hepatitis B virus (HBV) replication and hepatic fibrosis in children with chronic hepatitis B (CHB).