Open AccessImpact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells
Author(s) -
Yeon Ji Kim,
Bu Kyung Kim,
Seun Ja Park,
Jae Hyun Kim
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i29.4879
Subject(s) - fusobacterium nucleatum , gastrointestinal tract , fusobacterium , microbiology and biotechnology , medicine , immunology , biology , bacteria , bacteroides , porphyromonas gingivalis , genetics , periodontitis
Gut microbial dysbiosis contributes to the development and progression of colorectal cancer (CRC). Natural killer (NK) cells are involved in early defense mechanisms to kill infective pathogens and tumor cells by releasing chemokines and cytokines. To better understand the relationship between the gut microbiome and CRC, it was hypothesized here that a high abundance of Fusobacterium nucleatum ( F. nucleatum ) in the gastrointestinal tract could cause reduced NK cell activity.