Open AccessUbiquitin-specific protease 15 contributes to gastric cancer progression by regulating the Wnt/β-catenin signaling pathway
Author(s) -
Min Zhong,
Ling Zhou,
Zhi Fang,
Yangyang Yao,
JianPing Zou,
Jianping Xiong,
Xiaojun Xiang,
Jun Deng
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i26.4221
Subject(s) - deubiquitinating enzyme , wnt signaling pathway , cancer research , biology , gene knockdown , ubiquitin , small interfering rna , gene silencing , carcinogenesis , blot , microbiology and biotechnology , signal transduction , cancer , cell culture , biochemistry , transfection , gene , genetics
Ubiquitin-specific protease 15 (USP15) is an important member of the ubiquitin-specific protease family, the largest deubiquitinase subfamily, whose expression is dysregulated in many types of cancer. However, the biological function and the underlying mechanisms of USP15 in gastric cancer (GC) progression have not been elucidated.