Open AccessEnhancer of zeste homolog 2 contributes to apoptosis by inactivating janus kinase 2/ signal transducer and activator of transcription signaling in inflammatory bowel disease
Author(s) -
Jie Zhou,
Yang Yang,
Yiling Wang,
Yue Zhao,
Wenjing Ye,
Siyao Deng,
Jinyi Lang,
Shun Lü
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i22.3073
Subject(s) - ezh2 , cancer research , apoptosis , stat protein , occludin , stat3 , inflammatory bowel disease , biology , tumor necrosis factor alpha , chromatin immunoprecipitation , microbiology and biotechnology , immunology , medicine , pathology , chromatin , gene expression , promoter , tight junction , biochemistry , disease , gene , dna , genetics
Inflammatory bowel disease (IBD) is a prevalent worldwide health problem featured by relapsing, chronic gastrointestinal inflammation. Enhancer of zeste homolog 2 (EZH2) is a critical epigenetic regulator in different pathological models, such as cancer and inflammation. However, the role of EZH2 in the IBD development is still obscure.