Open AccessInterplay between nuclear factor erythroid 2-related factor 2 and inflammatory mediators in COVID-19-related liver injury
Author(s) -
Dandan Zhu,
Xuemei Tan,
Liqing Lu,
Sijia Yu,
Ru-Li Jian,
Xin-Fang Liang,
Yinting Liao,
Wei Fan,
Lucíia Barbier-Torres,
Austin J. Yang,
Heping Yang,
Ting Liu
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i22.2944
Subject(s) - inflammation , liver injury , covid-19 , medicine , immunology , transcription factor , coronavirus , disease , biology , infectious disease (medical specialty) , gene , biochemistry
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 is a global pandemic and poses a major threat to human health worldwide. In addition to respiratory symptoms, COVID-19 is usually accompanied by systemic inflammation and liver damage in moderate and severe cases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the expression of antioxidant proteins, participating in COVID-19-mediated inflammation and liver injury. Here, we show the novel reciprocal regulation between NRF2 and inflammatory mediators associated with COVID-19-related liver injury. Additionally, we describe some mechanisms and treatment strategies.