Open AccessCyclophosphamide-associated enteritis presenting with severe protein-losing enteropathy in granulomatosis with polyangiitis: A case report
Author(s) -
Hiroko Sato,
Toshikazu Shirai,
Hiroshi Fujii,
Tomonori Ishii,
Hideo Harigae
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i20.2657
Subject(s) - enteritis , granulomatosis with polyangiitis , medicine , protein losing enteropathy , cyclophosphamide , enteropathy , gastroenterology , pathology , vasculitis , disease , chemotherapy
Although cyclophosphamide (CPA) is the key drug for the treatment of autoimmune diseases including vasculitides, it has some well-known adverse effects, such as myelosuppression, hemorrhagic cystitis, infertility, and infection. However, CPA-associated severe enteritis is a rare adverse effect, and only one case with a lethal clinical course has been reported. Therefore, the appropriate management of patients with CPA-associated severe enteritis is unclear.