Open AccessAlleviation of acute pancreatitis-associated lung injury by inhibiting the p38 mitogen-activated protein kinase pathway in pulmonary microvascular endothelial cells
Author(s) -
Xiaoxin Zhang,
Haoyang Wang,
Xinyi Yang,
Ziqi Lin,
Na Shi,
Chen Chan-juan,
Linbo Yao,
Xunzhe Yang,
Jia Guo,
Qing Xia,
Ping Xue
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i18.2141
Subject(s) - p38 mitogen activated protein kinases , acute pancreatitis , protein kinase a , medicine , pancreatitis , mitogen activated protein kinase , pulmonary injury , lung , cancer research , kinase , microbiology and biotechnology , pulmonary fibrosis , biology
Previous reports have suggested that the p38 mitogen-activated protein kinase signaling pathway is involved in the development of severe acute pancreatitis (SAP)-related acute lung injury (ALI). Inhibition of p38 by SB203580 blocked the inflammatory responses in SAP-ALI. However, the precise mechanism associated with p38 is unclear, particularly in pulmonary microvascular endothelial cell (PMVEC) injury.