Open AccessDepletion of MRPL35 inhibits gastric carcinoma cell proliferation by regulating downstream signaling proteins
Author(s) -
Ling Yuan,
Jiaxin Li,
Yi Yang,
Yan Chen,
Tingting Ma,
Shuang Liang,
Baofeng Yang,
Lei Yu,
Nan Yang
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i16.1785
Subject(s) - cell growth , signal transduction , cancer research , downstream (manufacturing) , microbiology and biotechnology , gastric carcinoma , biology , cancer , chemistry , medicine , biochemistry , operations management , economics
Gastric carcinoma (GC) is a digestive system disease with high morbidity and mortality. However, early clinical detection is difficult, and the therapeutic effect for advanced disease is not satisfactory. Thus, finding new tumor markers and therapeutic targets conducive to the treatment of GC is imperative. MRPL35 is a member of the large subunit family of mitochondrial ribosomal protein. MRPL35 shows the characteristic of oncogene in colorectal cancer and esophageal cancer, which promotes the exploration of the correlation between MRPL35 and GC. We proposed that the expression of MRPL35 might be critical in GC.