Open AccessIntestinal bacterial overgrowth in the early stage of severe acute pancreatitis is associated with acute respiratory distress syndrome
Author(s) -
Xueying Liang,
Tian-Xu Jia,
Mei Zhang
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i15.1643
Subject(s) - acute pancreatitis , acute respiratory distress , medicine , small intestinal bacterial overgrowth , respiratory distress , pancreatitis , gastroenterology , respiratory system , stage (stratigraphy) , distress , lung , surgery , irritable bowel syndrome , biology , paleontology , clinical psychology
In the early stage of acute pancreatitis (AP), a large number of cytokines induced by local pancreatic inflammation seriously damage the intestinal barrier function, and intestinal bacteria and endotoxins enter the blood, causing inflammatory storm, resulting in multiple organ failure, infectious complications, and other disorders, eventually leading to death. Intestinal failure occurs early in the course of AP, accelerating its development. As an alternative method to detect small intestinal bacterial overgrowth, the hydrogen breath test is safe, noninvasive, and convenient, reflecting the number of intestinal bacteria in AP indirectly. This study aimed to investigate the changes in intestinal bacteria measured using the hydrogen breath test in the early stage of AP to clarify the relationship between intestinal bacteria and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Early clinical intervention and maintenance of intestinal barrier function would be highly beneficial in controlling the development of severe acute pancreatitis (SAP).