Open AccessEffects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis
Author(s) -
Monia Cecati,
Matteo Giulietti,
Alessandra Righetti,
Berina Šabanović,
Francesco Piva
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i15.1616
Subject(s) - biology , gene isoform , stromal cell , microarray analysis techniques , alternative splicing , cancer research , gene expression , gene expression profiling , microbiology and biotechnology , gene , genetics
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of death among cancers, it is characterized by poor prognosis and strong chemoresistance. In the PDAC microenvironment, stromal cells release different extracellular components, including CXCL12. The CXCL12 is a chemokine promoting the communication between tumour and stromal cells. Six different splicing isoforms of CXCL12 are known (α, β, γ, δ, ε, θ) but their role in PDAC has not yet been characterized.