Open AccessCurrent status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct
Author(s) -
Yuji Sakai,
Masayuki Ohtsuka,
Harutoshi Sugiyama,
Rintaro Mikata,
Shin Yasui,
Izumi Ohno,
Yotaro Iino,
Jun Kato,
Toshio Tsuyuguchi,
Naoya Kato
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i15.1569
Subject(s) - medicine , bile duct , intraductal papillary mucinous neoplasm , bile duct cancer , bile duct diseases , gastroenterology , pathology , radiology , general surgery , oncology , pancreas
Bile duct epithelial tumours showing papillary neoplasm in the bile duct lumen are present in the intrahepatic and extrahepatic bile ducts. Clinicopathological images of these tumours are distinctive and diverse, including histological images with a low to high grade dysplasia, infiltrating and noninfiltrating characteristics, excessive mucus production, and similarity to intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The World Health Organization Classification of Tumours of the Digestive System in 2010 named these features, intraductal papillary neoplasm of the bile duct (IPNB), as precancerous lesion of biliary carcinoma. IPNB is currently classified into type 1 that is similar to IPMN, and type 2 that is not similar to IPMN. Many of IPNB spreads superficially, and diagnosis with cholangioscopy is considered mandatory to identify accurate localization and progression. Prognosis of IPNB is said to be better than normal bile duct cancer.