Open AccessApolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis
Author(s) -
José Carlos Rodrigues Nascimento,
Lianna Cavalcante Pereira,
Juliana Magalhães C Rêgo,
Ronaldo Pereira Dias,
Paulo Goberlânio B Silva,
Silvio Alencar C Sobrinho,
Gustavo Coelho,
Ivelise Regina Canito Brasil,
Edmilson Ferreira de Oliveira-Filho,
James S. Owen,
Pierluigi Toniutto,
Reinaldo B. Oriá
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i11.1064
Subject(s) - cirrhosis , liver transplantation , medicine , gastroenterology , apolipoprotein e , liver disease , hepatocellular carcinoma , hepatitis c virus , fibrosis , hepatitis c , transplantation , inflammation , immunology , disease , virus
Hepatitis C virus (HCV) infection is responsible for a chronic liver inflammation, which may cause end-stage liver disease and hepatocellular carcinoma. Apolipoprotein E (protein: ApoE, gene: APOE ), a key player in cholesterol metabolism, is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.