Open AccessKynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice
Author(s) -
Chieko Tashita,
Masato Hoshi,
Akihiro Hirata,
Kentaro Nakamoto,
Tatsuya Ando,
Takayuki Hattori,
Yorimasa Yamamoto,
Hiroyuki Tezuka,
Hiroyuki Tomita,
Akira Hara,
Kuniaki Saito
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i9.918
Subject(s) - colitis , kynurenine , chemistry , sulfate , kynurenine pathway , pharmacology , medicine , immunology , tryptophan , biochemistry , amino acid , organic chemistry
Inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, is characterized by chronic intestinal inflammation leading to intestinal mucosal damage. Inflammatory bowel disease causes dysregulation of mucosal T cell responses, especially the responses of CD4 + T cells. Previously, we demonstrated that indoleamine-2,3-dioxygenase plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate (TNBS)-induced colitis. Although indoleamine-2,3-dioxygenase exerts immunosuppressive effects by altering the local concentration of tryptophan (Trp) and immunomodulatory Trp metabolites, the specific changes in immune regulation during colitis caused by Trp metabolites and its related enzymes remain unclear.