Open AccessRole of alcohol in pathogenesis of hepatitis B virus infection
Author(s) -
Murali Ganesan,
Allison Eikenberry,
Larisa Y. Poluektova,
Kusum K. Kharbanda,
Natalia A. Osna
Publication year - 2020
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v26.i9.883
Subject(s) - hepatitis b virus , liver disease , medicine , immunology , pathogenesis , hepatitis b , endoplasmic reticulum , alcohol abuse , disease , virus , alcoholic liver disease , virology , biology , cirrhosis , psychiatry , biochemistry
Hepatitis B virus (HBV) and alcohol abuse often contribute to the development of end-stage liver disease. Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically. Importantly, the mechanism by which alcohol promotes the progression of HBV-associated liver disease are not completely understood. Potential mechanisms include a suppressed immune response, oxidative stress, endoplasmic reticulum and Golgi apparatus stresses, and increased HBV replication. Certainly, more research is necessary to gain a better understanding of these mechanisms such that treatment(s) to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed. In this review, we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field.